Pancreatic ductal adenocarcinoma (PDAC) has still a dismal prognosis. Locally advanced pancreatic cancer (LAPC) accounts for\nthe 40% of the newdiagnoses.Current treatment options are based on chemo- and radiotherapy regimens. Local ablative techniques\nseem to be the future therapeutic option for stage-III patients with PDAC. Radiofrequency Ablation (RFA) and Irreversible\nElectroporation (IRE) are actually the most emerging local ablative techniques used on LAPC. Initial clinical studies on the use\nof these techniques have already demonstrated encouraging results in terms of safety and feasibility. Unfortunately, few studies on\ntheir efficacy are currently available. Even though some reports on the overall survival are encouraging, randomized studies are\nstill required to corroborate these findings. This study provides an up-to-date overview and a thematic summary of the current\navailable evidence on the application of RFA and IRE on PDAC, together with a comparison of the two procedures.
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